Skip Navigation
Skip to contents

J Pathol Transl Med : Journal of Pathology and Translational Medicine

OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
1 "Sung Weon Choi"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Original Article
PLAG1, SOX10, and Myb Expression in Benign and Malignant Salivary Gland Neoplasms
Ji Hyun Lee, Hye Ju Kang, Chong Woo Yoo, Weon Seo Park, Jun Sun Ryu, Yuh-Seog Jung, Sung Weon Choi, Joo Yong Park, Nayoung Han
J Pathol Transl Med. 2019;53(1):23-30.   Published online November 14, 2018
DOI: https://doi.org/10.4132/jptm.2018.10.12
  • 7,842 View
  • 335 Download
  • 23 Web of Science
  • 26 Crossref
AbstractAbstract PDF
Background
Recent findings in molecular pathology suggest that genetic translocation and/oroverexpression of oncoproteins is important in salivary gland tumorigenesis and diagnosis. Weinvestigated PLAG1, SOX10, and Myb protein expression in various salivary gland neoplasm tissues.
Methods
A total of 113 cases of surgically resected salivary gland neoplasms at the NationalCancer Center from January 2007 to March 2017 were identified. Immunohistochemical stainingof PLAG1, SOX10, and Myb in tissue samples was performed using tissue microarrays.
Results
Among the 113 cases, 82 (72.6%) were benign and 31 (27.4%) were malignant. PLAG1 showednuclear staining and normal parotid gland was not stained. Among 48 cases of pleomorphicadenoma, 29 (60.4%) were positive for PLAG1. All other benign and malignant salivary glandneoplasms were PLAG1-negative. SOX10 showed nuclear staining. In normal salivary gland tissuesSOX10 was expressed in cells of acinus and intercalated ducts. In benign tumors, SOX10 expressionwas observed in all pleomorphic adenoma (48/48), and basal cell adenoma (3/3), but not inother benign tumors. SOX10 positivity was observed in nine of 31 (29.0%) malignant tumors.Myb showed nuclear staining but was not detected in normal parotid glands. Four of 31 (12.9%)malignant tumors showed Myb positivity: three adenoid cystic carcinomas (AdCC) and onemyoepithelial carcinoma with focal AdCC-like histology.
Conclusions
PLAG1 expression is specificto pleomorphic adenoma. SOX10 expression is helpful to rule out excretory duct origin tumor,but its diagnostic value is relatively low. Myb is useful for diagnosing AdCC when histology isunclear in the surgical specimen.

Citations

Citations to this article as recorded by  
  • Immunohistochemical Characterization of a Large Cohort of Triple Negative Breast Cancer
    Rachel Han, Sharon Nofech-Mozes, Dina Boles, Hannah Wu, Nikolina Curcin, Elzbieta Slodkowska
    International Journal of Surgical Pathology.2024; 32(2): 239.     CrossRef
  • Proceedings of the 2024 North American Society of Head and Neck Pathology Companion Meeting, Baltimore, MD, March 24, 2024: Navigating Ancillary Studies in Basaloid/Blue Salivary Tumors
    Kristine S. Wong
    Head and Neck Pathology.2024;[Epub]     CrossRef
  • The Challenge of “Monomorphic” Mucoepidermoid Carcinoma—Report of a Rare Case with Pure Spindle-Clear Cell Morphology
    Xinyi Qu, Edwin Jun Chen Chew, Sathiyamoorthy Selvarajan, Bingcheng Wu, Abbas Agaimy, Fredrik Petersson
    Head and Neck Pathology.2023; 17(3): 864.     CrossRef
  • SOX10
    Albert L Sy, Mai P Hoang
    Journal of Clinical Pathology.2023; 76(10): 649.     CrossRef
  • Activating Transcription Factor 1 (ATF1) Immunohistochemical Marker Distinguishes HCCC from MEC
    Wafaey Badawy, Asmaa S. Abdelfattah, Haneen A. Sallam
    Journal of Molecular Pathology.2023; 4(3): 178.     CrossRef
  • Rare case of pleomorphic adenoma presenting as peritonsilar tumor
    Anđelina Jovanović, Svetlana Valjarević, Milan Jovanović
    Medicinska istrazivanja.2023; 56(3): 95.     CrossRef
  • Pleomorphic Adenoma of a Minor Salivary Gland of the Hard Palate: A Case Report
    Ishank Panchal, Anil Wanjari
    Cureus.2023;[Epub]     CrossRef
  • Advanced Diagnostic Methods for Salivary Glands Diseases: A Narrative Review Study
    Malak Mohammed AlOsaimi, Abdulaziz Mohammed AlSubaheen, Taif Saleh Jameel, Rand Abdulrahman AlSalamah, Dalal Naseh AlAnzi, Norah Ameen AlOushan, Fahad Fadhel AlShammari, Cristalle Soman
    Clinical Cancer Investigation Journal.2023; 12(4): 19.     CrossRef
  • Clinical Significance of SOX10 Expression in Human Pathology
    Hisham F. Bahmad, Aran Thiravialingam, Karthik Sriganeshan, Jeffrey Gonzalez, Veronica Alvarez, Stephanie Ocejo, Alvaro R. Abreu, Rima Avellan, Alejandro H. Arzola, Sana Hachem, Robert Poppiti
    Current Issues in Molecular Biology.2023; 45(12): 10131.     CrossRef
  • NR4A3 Immunostain Is a Highly Sensitive and Specific Marker for Acinic Cell Carcinoma in Cytologic and Surgical Specimens
    Kartik Viswanathan, Shaham Beg, Bing He, Taotao Zhang, Richard Cantley, Daniel J Lubin, Qiuying Shi, Zahra Maleki, Saeed Asiry, Rema Rao, Nora Katabi, Masato Nakaguro, William C Faquin, Peter M Sadow, Momin T Siddiqui, Theresa Scognamiglio
    American Journal of Clinical Pathology.2022; 157(1): 98.     CrossRef
  • Recent Advances on Immunohistochemistry and Molecular Biology for the Diagnosis of Adnexal Sweat Gland Tumors
    Nicolas Macagno, Pierre Sohier, Thibault Kervarrec, Daniel Pissaloux, Marie-Laure Jullie, Bernard Cribier, Maxime Battistella
    Cancers.2022; 14(3): 476.     CrossRef
  • Diagnostic accuracy of human transcriptional activator (Myb) expression by ELISA technique versus immunohistochemistry in detecting salivary gland carcinomas
    Yousra Refaey, OlfatGamil Shaker, Ayman Abdelwahab, ImanAdel Mohamed Abdelmoneim, Fat’heyaMohamed Zahran
    Journal of International Oral Health.2022; 14(1): 61.     CrossRef
  • SLUG is a key regulator of epithelial-mesenchymal transition in pleomorphic adenoma
    Hyesung Kim, Seung Bum Lee, Jae Kyung Myung, Jeong Hwan Park, Eunsun Park, Dong Il Kim, Cheol Lee, Younghoon Kim, Chul-Min Park, Min Bum Kim, Gil Chai Lim, Bogun Jang
    Laboratory Investigation.2022; 102(6): 631.     CrossRef
  • Assessment of MEF2C as a novel myoepithelial marker using normal salivary gland and pleomorphic adenoma: An immunohistochemical study
    Ikuko Takakura, Satoko Kujiraoka, Rika Yasuhara, Junichi Tanaka, Fumio Ide, Kenji Mishima
    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology.2022; 34(4): 523.     CrossRef
  • Update on selective special types of breast neoplasms: Focusing on controversies, differential diagnosis, and molecular genetic advances
    Shi Wei
    Seminars in Diagnostic Pathology.2022; 39(5): 367.     CrossRef
  • Cutaneous Melanomas: A Single Center Experience on the Usage of Immunohistochemistry Applied for the Diagnosis
    Costantino Ricci, Emi Dika, Francesca Ambrosi, Martina Lambertini, Giulia Veronesi, Corti Barbara
    International Journal of Molecular Sciences.2022; 23(11): 5911.     CrossRef
  • Distinct clinicopathological and genomic features in solid and basaloid adenoid cystic carcinoma of the breast
    Juan Ji, Fang Zhang, Fanglei Duan, Hong Yang, Jun Hou, Yang Liu, Jie Dai, Qiong Liao, Xian Chen, Qingsong Liu
    Scientific Reports.2022;[Epub]     CrossRef
  • NR4A3 fluorescence in situ hybridization analysis in cytologic and surgical specimens of acinic cell carcinoma
    Qiuying Shi, Bin Zhang, Caroline Bsirini, Liqiong Li, Ellen J. Giampoli, Kelly R. Magliocca, Michelle Reid, Zhongren Zhou
    Human Pathology.2022; 127: 86.     CrossRef
  • Evaluation of NR4A3 immunohistochemistry (IHC) and fluorescence in situ hybridization and comparison with DOG1 IHC for FNA diagnosis of acinic cell carcinoma
    John M. Skaugen, Raja R. Seethala, Simion I. Chiosea, Michael S. Landau
    Cancer Cytopathology.2021; 129(2): 104.     CrossRef
  • MYB-NFIB Translocation by FISH in Adenoid Cystic Carcinoma of the Head and Neck in Nigerian Patients: A Preliminary Report
    Adepitan A. Owosho, Olufunlola M. Adesina, Oluwole Odujoko, Olujide O. Soyele, Akinwumi Komolafe, Robert Bauer, Kallie Holte, Kurt F. Summersgill
    Head and Neck Pathology.2021; 15(2): 433.     CrossRef
  • Liquid-based cytology of oral brushings in a case of adenoid cystic carcinoma arising from the palate
    Ryo MAKINO, Akihiko KAWAHARA, Hideyuki ABE, Yorihiko TAKASE, Chihiro FUKUMITSU, Kazuya MURATA, Tomoko YOSHIDA, Yukako SHINODA, Yoshiki NAITO, Jun AKIBA
    The Journal of the Japanese Society of Clinical Cytology.2021; 60(1): 33.     CrossRef
  • MYB Translocations in Both Myoepithelial and Ductoglandular Epithelial Cells in Adenoid Cystic Carcinoma: A Histopathologic and Genetic Reappraisal in Six Primary Cutaneous Cases
    Keisuke Goto, Kazuyoshi Kajimoto, Takashi Sugino, Shin-ichi Nakatsuka, Makoto Yoshida, Mai Noto, Michihiro Kono, Toshihiro Takai
    The American Journal of Dermatopathology.2021; 43(4): 278.     CrossRef
  • Co-expression of Myoepithelial and Melanocytic Features in Carcinoma Ex Pleomorphic Adenoma
    Costantino Ricci, Federico Chiarucci, Francesca Ambrosi, Tiziana Balbi, Barbara Corti, Ottavio Piccin, Ernesto Pasquini, Maria Pia Foschini
    Head and Neck Pathology.2021; 15(4): 1385.     CrossRef
  • Juvenile onset pleomorphic adenoma presenting as giant tumor of parotid gland in a young female
    Surender Verma, Shivika Aggarwal, Pradeep Garg, Anjali Verma, Mridul Gera, SwaranS Yadav
    Journal of Dr. NTR University of Health Sciences.2021; 10(4): 286.     CrossRef
  • Cytopathology and diagnostics of Warthin's tumour
    Mirna Sučić, Nives Ljubić, Leila Perković, Dunja Ivanović, Leo Pažanin, Tena Sučić Radovanović, Dubravka Župnić‐Krmek, Fabijan Knežević
    Cytopathology.2020; 31(3): 193.     CrossRef
  • Clear cell papillary neoplasm of the breast with MAML2 gene rearrangement: Clear cell hidradenoma or low-grade mucoepidermoid carcinoma?
    Raima A. Memon, Carlos N Prieto Granada, Shi Wei
    Pathology - Research and Practice.2020; 216(10): 153140.     CrossRef

J Pathol Transl Med : Journal of Pathology and Translational Medicine